Coagulopathy (assessment and treatment selection) involves comprehensive assessment of hemostatic disorders and selection of personalized coagulation therapy to prevent bleeding or thrombosis. Treatment choice is determined by underlying cause and disease severity. For inherited coagulopathy associated with specific clotting factor deficiencies, replacement therapy is recommended. For acquired coagulopathies, treatment focuses on the underlying cause. Modern diagnostic methods and a wide range of hemostatic agents allow patient to lead an active life without fear of life-threatening bleeding even in the case of a severe coagulation disorder.